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COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer

INTRODUCTION The emerging SARS-CoV-2 Omicron (B.1.1.529) variant has caused considerable concern about the future of containing the ongoing COVID-19 pandemic (World Health Organization, 2021). First isolated in late November of 2021, the Omicron variant harbors a staggering 30-40 mutations in the viral spike (S) protein, including substantial changes to the S-receptor-binding domain, that have produced …

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Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: The COVID-19 SEIMC score

Objective To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms.Design Multivariable prognostic prediction model.Setting 127 Spanish hospitals.Participants Derivation (DC) and external validation (VC) cohorts were obtained from multicentre and singlecentre databases, including 4035 and 2126 patients with confirmed COVID-19, respectively.Interventions Prognostic variables were identified using multivariable logistic …

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Morbidity and Mortality Weekly Report Early Release

Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers — Eight U.S. Locations, December 2020–March 2021 Messenger RNA (mRNA) BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) COVID-19 vaccines have been shown to be effective in preventing symptomatic COVID-19 in …

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